PDRN (Polydeoxyribonucleotide)

Anti-aging DNA therapy that teaches your skin to be young again.

 

Skin ageing is inevitable. This starts as early as mid 20’s. As we age, we suffer from deterioration in facial skin tone, elasticity, hydration, wrinkles, pores and scarring. This is why it is crucial to start early. With advanced technology these days, delaying ageing process is no longer challenging

What is the difference between PDRN vs PN?

Polynucleotides (PNs) refer to a broader group of molecules. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are all PNs. On the other hand, PRDN – Polydeoxyribonucleotides, refer to a subtype of PNs. PDRN is a proprietary and registered DNA derived drug. It is a mixture of deoxyribonucleotides withmolecular weights between 50 and 1,500 KDa and it is derived from Oncorhynchus mykiss (Salmon trout) or Oncorhynchus keta (Chum Salmon) sperm DNA.

PDRN Pharmacokinetics

The half-life is of 3 h and it is not influenced by dosage. The drug stimulates the initiation of a cascade of events involving a number of transduction effectors that last much more than its plasma half–life. Therefore, the pharmacodynamics effects of PDRN may be much longer than anticipated by its pharmacokinetic profile. Due to its chemical structure, plasmatic carrier proteins do not bind PDRN, but it is found free in plasma. The drug is not metabolized by the liver and there is no evidence for a first-passage metabolism. Instead, the drug is mainly degraded by unspecific plasma DNA nucleases, or by nucleases bound to cell membranes leading to oligo and mononucleotides. PDRN degradation gives rise to the formation of nucleosides and nucleotides that become available for the main activity: the binding to the adenosine A2A receptor. PDRN fragments are then excreted in the urine (∼65%) and to a lesser extent in the feces.

Mechanism of action

Adenosine activates four distinct adenosine receptors indicated as A1, A2A, A2B, and A3. These receptors are widely expressed and implicated in several physiological and pathological functions. The A2A receptor play a central role in modulating inflammation, oxygen consumption, ischemia, cell growth, and angiogenesis.

Cell growth is accompanied by internalization of PDRN-derived nucleotides to offer purine and pyrimidine rings for the “salvage pathway.” In fact, damaged or hypoxic tissue very often cannot undergo to the DNA “de novo” synthesis . Under these conditions, salvage pathways operate to recover bases and nucleosides generated from the breakdown of DNA and RNA. The salvaged bases can be then transformed into nucleotides and reincorporated into DNA. PDRN generates nucleotides and nucleosides that can contribute to DNA formation, thus reactivating normal cell proliferation and growth pattern.

PDRN has been also tested in primary chondrocytes, where induced a physiological accumulation of the extracellular matrix with reduced proteoglycan degradation, reducing matrix metalloproteinases 2 and 9. Moreover, PDRN synergizes with glucosamine in reducing extracellular matrix gene expression, thus reducing its degradation.

 

 

PDRN may also protect cells from UV- induced DNA damage. Exposure of human dermal fibroblasts to ultraviolet B radiation causes accumulation of dangerous photoproducts such as cyclobutane pyrimidine dimers (CPDS). PDRN addition to the cell culture immediately after irradiation resulted in p53 protein activation and in enhancing DNA repair likely due to the priming of the salvage pathway.

Another important aspect useful in regenerative medicine could be related to PDRN ability to increase the proliferation of human pre-adipocytes. As a matter of fact, adipose tissue represents a relevant source of adult stem cells, thus PDRN may be used for therapeutic and regenerative purposes.

 

Pharmacological Properties of PDRN

Tissue Repairing, Wound Healing and Therapeutic Angiogenesis

PDRN Anti-Inflammatory Activity

The adenosine A2A receptor activation results in a robust anti-inflammatory effect, and it represents an interesting target for the molecular design of anti-inflammatory agents.

 

Anti-Ischemic Effects of PDRN

Adenosine contributes to the mechanisms underlying ischaemia/reperfusion injury and the A2A receptor has been indicated as a therapeutic strategy to modulate the ischemic insult.

 

What Benefits Does PDRN Have?

PN/PDRN’s healing properties have several beneficial effects on the skin

  • Improved skin elasticity
  • Improved Hydration
  • Reduced fine lines and wrinkles
  • Skin repair – with improved skin barrier function
  • Skin normalization – thickening of skin, regulation of oil production
  • Improved skin tone
  • Improved skin texture

The conditions which PDRN/PN shown to treat include:

  • Dark eye circles
  • Enlarged pores
  • Skin sagging
  • Enlarged pores
  • Dull skin
  • Wrinkles and fine lines
  • Acne scars
  • Stretch Marks

PDRN has been reported to react with cross-linked Hyaluronic Acid (HA) fillers, causing granuloma formation (this shows up as hard nodules). The proposed mechanism is through reaction of the polynucleotides with BDDE – the chemical used for cross linking in most fillers. Hence, you are advised NOT to have  PN/PDRN if you have had cross-linked HA fillers within a year.

Skin Boosters Vs PDRN

Skinboosters is a filler treatment which improves skin hydration, firmness and luminosity, through micro-injections of a very soft hyaluronic acid filler into the skin. Fillers typically work by filling up volume deficiencies and lifting the skin. Skinboosters, on the other hand, are extremely soft. Instead of exerting mechanical effects, they work via its biochemical properties.

The table below details the differences between these 2 treatments:

Features SkinBoosters  PDRN 
Type of Treatment ·      Filler treatment ·      Skin healing and wound repair treatment
Contents ·      Stabilized Hyaluaronic Acid (HA) ·      Polyneucleotide (PN) derived from salmon DNA
What It Does ·      Addresses signs of aging·      HA draws water to the skin to keep it hydrated and plump

·      Prevents moisture loss

·      Reverses aging by repairing skin at cellular level·      PDRN/ PN repairs damaged dermal cells

·      Restore abnormal, aging cells

Benefits ·      Rehydrate severely dry skin·      Smoother skin texture

·      Firmer, more elastic skin

·      Luminous, translucent skin

·      Repair severely damaged skin·      Reduce appearance of pigmentation and scars

·      Accelerate wound healing

·      Regulate oily skin

·      Minimize enlarged pores

Best For People with ·      Severely dry skin·      Superficial wrinkles and fine lines ·      Severely damaged, aging skin·      Scars especially acne scars

·      Enlarged pores with oily skin

Recommended Treatment Plan ·      First 3 treatments to be done 4 weeks apart·      Subsequent treatments can be done every 6 months ·      First 4 treatments to be done 2 – 4 weeks apart·      Subsequent treatments can be done every 6 months
Side Effects ·      Skin may appear mildly red and swollen immediately after treatment·      Injection sites may appear lumpy temporarily if injection depth is too shallow ·      May develop temporary rash·      Skin may appear mildly red and swollen immediately after treatment

·      Not suitable for vegetarians

 

 

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